Doctors treat pemphigus vulgaris primarily with corticosteroid drugs such as prednisone or prednisolone, notes Healthline. Doctors may also prescribe antibiotics, antivirals and antifungals to prevent other infections and prescribe drugs and other treatments to help with pain relief and to fight the side effects of the corticosteroids. In extreme cases, a doctor may perform a plasmapheresis, during which the patient's plasma is replaced to remove the antibodies attacking the blood.
Loss of muscle mass, stomach ulcers, increased susceptibility to infection and eye problems are all potential side effects of the high doses of corticosteroids doctors use to treat pemphigus vulgaris, states Healthline. Patients taking corticosteroids may also have to eat a low sugar diet and take additional vitamins or medications to deal these side effects. Doctors may also prescribe medications to suppress the immune system to keep doses of corticosteroids low. Patients with severe mouth blisters caused by pemphigus vulgaris may have to consume nutrients intravenously.
People with pemphigus vulgaris may also treat the resulting blisters with numbing lozenges, lotions, wet dressings and pain medications, notes Healthline. Eating soft foods, avoiding spicy or acidic foods that irritate blisters, and avoiding the sun can also help relieve the symptoms of pemphigus vulgaris. There is no cure for pemphigus vulgaris, as of 2015; however patients can go into remission after receiving corticosteroids.