Treat minor burns with skin blisters by cooling the burn with cool water or a clean towel that is dampened with cool water for 10 to 15 minutes, recommends Mayo Clinic. Avoid breaking small blisters, but if blisters break naturally, clean the area with water and mild soap, and treat it with an antibiotic ointment before covering it with a nonstick gauze bandage.
Consult with a medical professional for burns that have skin blisters; a tetanus shot may be necessary, according to Mayo Clinic. Treat pain from a burn by taking acetaminophen, naproxen sodium or ibuprofen. An aloe vera gel, lotion or moisturizer may also help to relieve pain associated with burns that produce skin blisters.
For large blisters that develop as a result of a burn, seek medical attention to have the blisters removed, suggests Mayo Clinic. Burns that are large or blisters that are red, swollen and oozing need evaluation by a medical professional to prevent the risk of infection.
First degree burns with skin blisters typically cause pain, redness and swelling, whereas second degree burns may produce red, white or splotchy skin in addition to pain, blisters and swelling, explains Mayo Clinic. Third degree burns are the most severe and may cause difficulty breathing or carbon monoxide poisoning.