To treat a blister on the hand, cover the area with an adhesive bandage while keeping the blister intact, recommends Mayo Clinic. If the blister causes pain, drain the fluid by puncturing the skin with a sterile needle.
Use a loose bandage to protect any small, pea-sized blister or blood blister, and let it heal on its own, avoiding the activity that caused the blister, advises WebMD. Avoid draining a blister if it may be from a contagious disease such as chickenpox or if you have a condition such as HIV or diabetes. If a blister opens by itself, gently wash the palm with soap and water, and leave the flap of skin in place unless it has pus underneath or is excessively dirty. Smooth the flap of skin over the raw skin before applying an antibiotic ointment and bandaging the area.
To drain a blister while leaving the skin intact, swab the blister with iodine after washing it with soap and water, instructs Mayo Clinic. Sterilize a sharp, unused needle with rubbing alcohol, and puncture the blister in several places around its edges. After letting the fluid drain, apply an ointment and a gauze bandage, changing the dressing every day until the wound heals. Use gloves to prevent future blisters on the palms of the hands.