Is Trazodone a Controlled Substance?

trazodone-controlled-substance Credit: divine_harvester/CC-BY-2.0

Trazodone hydrochloride is not a controlled substance, according to Clinical studies have not indicated drug-seeking behavior in Trazodone users, but systematic studies on the drug's potential for abuse have not been conducted.

According to, fatal overdoses of Trazodone have occurred when other central nervous system depressants, such as alcohol and diazepam, were used simultaneously. Overdose of Trazodone alone has led to electrocardiogram (ECG) changes, priapism, respiratory arrest and seizures. More frequent reactions to Trazodone overdoses include drowsiness and vomiting. Doctors prescribe Trazodone hydrochloride tablets to treat major depressive disorder in adults. Clinical trials have proven the drug's efficacy in treating major depressive disorder (MDD).