Transient acantholytic dermatosis, also known as Grover's disease, is a rare skin condition in which the substance that holds skin cells together breaks down and the cells separate, resulting in red, raised, fluid-filled bumps, explains the National Organization for Rare Disorders. The condition is most common in men over 40 years old, and studies suggest it has associations with skin damage from sun exposure.
The bumps transient acantholytic dermatosis causes are solid to the touch and often itchy, according to the National Organization for Rare Disorders. In some people, this itching can be severe. The fluid within the blisters is thin and watery, and they often contain hair follicles that appear as depressions within the bump. The skin can exhibit excessive growth above the blisters as a response to this condition.
Treatment for transient acantholytic dermatosis includes antihistamines and topical steroids to relieve itching, the National Organization for Rare Disorders reports. This relief is often temporary. Other treatments that are sometimes effective include selenium sulfide, tetracycline and oral retinoids. No treatment is universally effective, and in some cases in which a treatment is effective, the condition returns later. Without treatment, the condition can last from a few weeks to several months, but it eventually resolves naturally.