The best time of day to take Cymbalta depends on the person taking this medicine and any types of side effects or reactions he may have to taking it. According to WebMD, some side effects include sleepiness or drowsiness, nausea and nervousness, which make taking the medication at night preferable.
WebMD recommends taking Cymbalta as prescribed by a doctor. It also highly recommends taking the medication close to the same time everyday to see the maximum effect. If a dose is missed, it should be taken as soon as possible; however, if it is close to the time for the next dose, then the missed dose should be skipped and the next dose can be taken. Cymbalta should be taken with a meal if it upsets the stomach, and it should never be taken with alcohol.