Symptoms of one type of systemic candida, called candidemia, include fever; candidal endophthalmitis in approximately 10 to 28 percent of patients; macronodular skin lesions in approximately 10 percent of patients; and septic shock, which can cause high blood pressure, tachypnea and tachycardia, according to Medscape. The other type of systemic candida, known as disseminated candidiasis, can cause fever and septic shock.
Patients with either type of systemic candida may have a fever that lasts for several days and does not respond to broad-spectrum antimicrobials, explains Medscape. This fever may be the only symptom of systemic candida.
Invasive disease can cause candidemia, but intravascular catheter-related candidiasis, suppurative thrombophlebitis and endocarditis can also cause this type of systemic candida infection, notes Medscape. Patients with intravascular catheter-related candidiasis should recover quickly once a doctor prescribes antifungals and removes the catheter. However, suppurative thrombophlebitis does not respond to catheter removal and antifungals; it often progresses to sepsis. Various Candida species cause approximately 60 percent of fungal endocarditis cases. Risk factors for developing fungal endocarditis include chemotherapy, use of prosthetic valves or central venous catheters, and intravenous heroin use.
Research associates disseminated candidiasis with single or multiple organ infections, states Medscape. Blood testing is not a reliable form of testing because 40 to 60 percent of patients with disseminated candidiasis receive negative test results.