Symptoms of Stage IV lymphoma, which is classified into Hodgkin and non-Hodgkin lymphoma, depend on the type and severity of the cancer and include weight loss, recurring fevers, night sweats and aggravating fatigue, states Healthline. Most lymphoma patients have B-cell lymphoma, but some have lymphoma that affects T cells.
Non-Hodgkin lymphoma reaches Stage IV when it affects other organs besides the lymph nodes, explains Healthline. Aggressive non-Hodgkin lymphoma progresses quickly, whereas indolent non-Hodgkin lymphoma develops slowly. Patients with Stage IV lymphoma experience a painful chest, panting or coughing, particularly when lymphomas push into the trachea or superior vena cava, which is a large vein responsible for delivering blood from the head and arms to the heart.
Stage IV lymphoma may also involve itching, lack of appetite, stomach pain, stomach swelling or nausea, according to Healthline. Some patients experience vomiting and constipation, especially when lymphoma leads to fluid accumulation in the abdomen.
Treatment for diffuse large B-cell lymphoma, a common subtype of non-Hodgkin lymphoma, involves taking chemotherapy drugs for up to six months, notes Healthline. Age, the ability to manage daily activities and the level of lactate dehydrogenase in blood all affect the prognosis of lymphoma. The Leukemia and Lymphoma Society offers local support groups.