The only symptom that is generally shared between fibromyalgia and pleurisy is pain, according to Mayo Clinic. The two diseases have such different causes and locations that they do not generally share many symptoms.
Although both pleurisy and fibromyalgia have pain as a major symptom, the pain is actually not very similar in the two cases, according to Mayo Clinic. Fibromyalgia is associated with widespread pain that causes a dull ache across the entire body (on both sides of the body and both above and below the waist); this pain must be sustained, and to be diagnosed must occurred for at least three months. In definitive contrast, the pain associated with pleurisy is sharp and gets worse when breathing, coughing, or sneezing. Instead of being distributed, pain associated with pleurisy is generally located within the chest.
Pleurisy and fibromyalgia also have numerous distinct symptoms, writes Mayo Clinic. Fibromyalgia often presents with fatigue and sleep disruptions, as well as "fibro fog": difficulty focusing or paying attention as a result of the condition. Fibromylagia patients can also experience numerous other problems including headaches, depression, and abdominal pain or cramping. On the other hand, pleurisy often causes shortness of breath as sufferers attempt to minimize their breathing. This disease can also present with a cough or fever, although this is not true in every case.