Premarin withdrawal symptoms may include the return of the menopausal symptoms an individual experienced before taking hormone replacement therapy. The severity of withdrawal symptoms depends on the severity of a woman's menopausal symptoms prior to starting hormone replacement therapy, reports Women to Women.
Menopausal symptoms that may return after quitting Premarin include hot flashes, night sweats and vaginal dryness, says WebMD. Women can lessen the risk of experiencing severe withdrawal symptoms by gradually tapering off Premarin under a doctor's supervision. Women can manage the symptoms of menopause without systemic hormone replacement therapy using various approaches. Antidepressants such as Prozac and Celexa relieve hot flashes and combat mood swings. Hot flashes may also be managed by setting the thermostat lower and dressing in layers.
Prescription vaginal estrogen works best to relieve vaginal dryness and irritation, according to WebMD, but nonhormonal lubricants may be effective as well. Many women chose to stop taking hormonal replacement therapy such as Premarin after a government study made the public aware of health risks and side effects of hormone replacement therapy, says Women to Women. After the release of the Women's Health Initiative study in 2002, millions of women chose to stop taking hormone replacement therapy.