What Are the Symptoms of Paget's Disease?


Symptoms of Paget's disease may include hearing loss, headaches, deformity of the legs, and tingling or numbness in an arm or leg, as reported by Mayo Clinic. Specific symptoms a patient experiences depend on the body part affected. Eventual complications can include osteoarthritis and bone fractures.

Paget's disease disrupts the normal process for recycling bone, causing bone to breakdown faster than the body can properly compensate for, as stated by Mayo Clinic. Sometimes, the body responds by increasing the rate at which bone grows, resulting in soft, painful and misshapen bones. In most cases, Paget's disease produces no symptoms, and doctors usually discover the disease when testing patients for other disorders. Paget's disease most frequently affect a leg, the skull, the spine and the pelvis.

X-rays and bone scans can reveal the signs of Paget's disease, says Mayo Clinic. Active cases of the disease cause unusually high concentrations of certain chemicals in the bloodstream, which blood tests can detect. To treat Paget's disease, doctors typically prescribe biphosphate drugs, such as alendronate, ibandronate, pamidronate or risedronate. Calcitonin is an alternative for people who cannot tolerate biphosphates. In severe cases, patients suffering from Paget's disease may require surgery to repair damage to bones and surrounding tissues.