Monoclonal gammopathy usually does not cause symptoms; however, depending on which illness causes the condition, symptoms can occur, such as anemia, recurring infection, weight loss, fatigue and vision problems, according to University of Rochester Medical Center. Other symptoms include numbness or tingling in the extremities, headaches, mental changes, swelling and bleeding. Monoclonal gammopathy is a condition in which the blood contains abnormal protein levels. Once physicians discover the condition, they typically monitor their patients using scheduled exams and blood work.
People with monoclonal gammopathy of undetermined significance have a higher risk of developing
bone marrow and blood diseases than other individuals, explains University of Rochester Medical Center. Doctors often discover the condition when collecting blood samples for other reasons, which is called an incidental finding. Physicians often conduct more tests, such as blood and urine screenings, after incidental findings of abnormal proteins. The test results may lead to additional testing to establish diagnoses.
Scientists do not know why monoclonal gammopathy of undetermined significance develops, notes University of Rochester Medical Center. Possible causal factors include autoimmune conditions, infections and environmental conditions, but research has not established clear relationships to the condition. Experts have established that the abnormal protein development is not due to consuming dietary proteins or any specific diet. Generally, people with the condition never develop serious disorders. Some of the more serious conditions that can develop include plasma cell leukemia, multiple myeloma, non-Hodgkin lymphoma and primary amyloidosis.