Symptoms of Melkersson Rosenthal syndrome include recurring orofacial swelling, facial paralysis and a fissured tongue, according to PubMed Central. The patient's lips may swell and have a reddish-brown discoloration, reports National Institute of Neurological Disorders and Stroke.
The first symptom of Melkersson Rosenthal syndrome is usually swelling of the lower or upper lip, according to National Organization of Rare Disorders. The patient may also experience swelling of the eyelids, one or both cheeks and, in rare cases, one side of the scalp. This initial swelling may last a few hours, but subsequent episodes may be more severe and last longer or become permanent. The enlarged lips are cracked and painful and appear discolored.
In some cases, headaches, fever and visual problems accompany the lip swelling, notes the National Organization of Rare Disorders. Twenty to 40 percent of patients have a fissured tongue. Secretions from the salivary gland may reduce, and the patient may have diminished sense of taste.
Thirty percent of patients experience facial palsy, reports the National Organization of Rare Disorders. This is weakness of the facial muscles, according to WebMD. Facial palsy often occurs after several episodes of lip swelling, though it may also be the first symptom. Weakness of the facial muscles may affect one or both sides. Facial palsy resolves itself in the beginning, but it may become permanent after several episodes.
Some individuals have all the major symptoms of Melkersson Rosenthal syndrome, though some patients have only one or two symptoms, according to WebMD.