Diseases associated with increased basophil in the blood include Varicella infection, myeloproliferative disease, collagen vascular disease or allergic reaction, according to the U.S. National Library of Medicine. Individuals who have had a splenectomy may also have higher amounts of basophil in their blood.
Varicella is better known as chicken pox, according to the Centers for Disease Control and Prevention. Complications sometimes associated with Varicella include toxic shock syndrome, necrotizing fasciitis, septicemia, osteomylelitis, septic arthritis and bacterial pneumonia.
Myeloproliferative neoplasms affect the body's blood cells, according to the National Cancer Institute. Some of these diseases can cause bone marrow to create too many of a certain type of blood cell, including basophils.
Collagen vascular disease describes a class of autoimmune disorders that includes dermatomyositis and psoriatic arthritis, according to MedlinePlus. These diseases cause the body's immune system to attack its own tissues. Other examples include systemic lupus erythematosus, scleroderma and rheumatoid arthritis.
A blood differential can determine the level of basophils in the blood, according to the U.S. National Library of Medicine. The test determines the relative proportions of the five types of white blood cells in the blood and determines if any of them are abnormally shaped or are immature.