Symptoms of familial combined hyperlipidemia include cramping of calves while walking, chest pain, sores on toes that do not heal and sudden stroke-like symptoms, such as loss of balance, trouble speaking or weakness in a leg or arm, according to Medline Plus. Often symptoms are not present for some years.
Familial combined hyperlipidemia is a common hereditary disorder that increases fats in the blood, Medline Plus explains. It can lead to heart attacks and strokes in young people and also can contribute to obesity and glucose intolerance. Alcoholism, diabetes and hypothyroidism can make the condition worse.
Researchers have not located the gene responsible for familial combined hyperlipidemia, so as of 2015 the only indicators of the condition are a family history of high cholesterol and early heart disease, says Medline Plus. People with familial combined hyperlipidemia often have high triglycerides as teenagers.
Lifestyle changes are the first line of defense for familial combined hyperlipidemia, reports Medline Plus.
Regular exercise and avoiding refined sugar and saturated fat can help lower cholesterol levels. Doctors may also prescribe medication such as statins to lower cholesterol levels. Early treatment and compliance with lifestyle changes determine how well a patient will live with the condition.