Symptoms of Charcot-Marie-Tooth disease typically become present in adolescence or early adulthood, according to the National Institute of Neurological Disorders and Stroke. It is not rare for symptoms to emerge in mid-adulthood.
Weakness and numbness are the primary symptoms of CMT disease, according to the Charcot-Marie-Tooth Association. Symptoms start at the feet and move upward as the disease progresses, eventually reaching the arms and hands in some individuals. An atrophied calf muscle, difficulty balancing and a very high arch are also common symptoms.
CMT disease is an inherited neurological disorder and affects one in 2,500 people, as the the National Institute of Neurological Disorders and Stroke indicates. Except in rare cases, CMT disease is not fatal, and life expectancy is not affected.