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What are symptoms of Charcot-Marie-Tooth disease?

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Symptoms of Charcot-Marie-Tooth disease include weakness in the feet, ankles and legs, as well as awkward gait and frequent falling or tripping, according to Mayo Clinic. Physiological differences, including curled toes and high arches, may also signal the disease. Symptoms vary widely between patients, and as the disease progresses it may also affect the hands and arms.

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Additional symptoms of CMT include loss of muscle mass in the legs and feet, as well as an increasing loss of feeling in the feet and legs, reports Mayo Clinic. Patients may find it difficult to run or to lift the foot at the ankle.

CMT encompasses a group of hereditary conditions that damage nerves in the legs and sometimes the arms, explains Mayo Clinic. It is also called hereditary motor and sensory neuropathy.

Symptoms of CMT typically begin in adolescence or early adulthood, states Mayo Clinic. Some patients don't experience symptoms until middle age. CMT progresses slowly over time and can lead to disability, notes the Charcot-Marie-Tooth Association. Patients may experience pain related to the nerve damage or the orthopedic problems caused by the condition.

As of 2015, no cure exists for CMT, according to the Charcot-Marie-Tooth Association. Patients may undergo surgery or use orthopedic equipment to preserve their ability to walk.

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