Bright’s disease refers to glomerulonephritis, or glomerular disease, according to Encyclopaedia Britannica. Symptoms of glomerulonephritis include discoloration of or foam in the urine; elevated blood pressure; fluid retention; swelling of the face, abdomen or extremities; and fatigue, states Mayo Clinic.
Glomerulonephritis occurs when the glomeruli in the kidney, which filter fluid from the bloodstream, become inflamed, explains Mayo Clinic. Inflammation can occur gradually in chronic cases or suddenly in acute cases. Infections and other diseases and health factors can contribute to the disease, but physicians are not always able to identify the exact cause. Infections that contribute to glomeruli inflammation include strep throat, bacterial endocarditis, and, in rare cases, impetigo. Viral infections such as hepatitis and HIV can also contribute to glomerulonephritis.
Lupus causes inflammation throughout the body and can cause glomeruli disease when it spreads to the kidneys, according to Mayo Clinic. The disease can also result from other conditions, such as immunoglobulin A nephropathy, Goodpasture’s syndrome, polyarteritis and Wegener’s granulomatosis. Individuals with high blood pressure or diabetes have an increased risk of developing the disease. As the glomeruli become less effective, glomerulonephritis may cause additional health problems, such as acute kidney failure, chronic kidney disease and elevated blood pressure.