The most common symptom of bone cancer in the arm is a deep or dull ache, according to Cancer Treatment Centers of America. In the early stages, the pain sometimes only happens at night or during periods of activity, but it becomes more chronic as the cancer advances.
Other symptoms of bone cancer in the arm include swelling in the sites where pain takes place. When cancerous cells weaken the bone enough, fractures result. If the cancer in the arm is near the elbow or shoulder, the cancer threatens mobility. Unexplained weight loss and fatigue are also possible symptoms, notes Cancer Treatment Centers of America.