Symptoms of amyloidosis include joint pain, shortness of breath, weakness and weight loss. Other symptoms such as numbness in the limbs, an enlarged tongue, anemic signs, changes in skin color and clay-colored stool may also be experienced, notes WebMD. The symptoms are often imperceptible and vary greatly depending on the affected organ.
Amyloidosis is caused by the accumulation of an anomalous protein called amyloid that can collect anywhere in the body, states Mayo Clinic. When amyloid accumulates in the heart, a person may experience shortness of breath with simple activity or exhibit signs of heart failure such as swelling of the ankles and feet, nausea, and fatigue, notes WebMD.
Amyloid deposits in the kidneys affect normal functioning of the organs and can result in high levels of protein in the urine. A person with renal amyloidosis may also experience symptoms of kidney failure such as puffiness around the eyes and swelling of the ankles and feet, reports WebMD. Gastrointestinal amyloidosis interferes with digestion and may cause symptoms such as diarrhea, stomach pain, nausea and decreased appetite.
Amyloid neuropathy damages the peripheral nerves that carry information between the brain and the spinal cord. Symptoms include balance problems, sweating, lightheadedness and the inability to control the bowel and bladder, states WebMD.