Sucrolose, also known as Splenda, has digestive side effects including a reduction in the amount of beneficial bacteria in the gastrointestinal tract, according to Prevention. Some people have sensitivity reactions to the sucrolose molecule that can result in may result digestive side effects, according to Women to Women.
Research has shown that sucrolose may reduce the amount of good bacteria in the gut by up to 50 percent, which could lead to weight gain and obesity, explains Prevention.
Some people have sensitivity reactions to sucrolose, meaning their bodies are unable to process this molecule. This can result in digestive side effects include diarrhea, intestinal cramping and stomach pain, according to Women to Women.