Estrogen replacement and tranexamic acid are two medications that may be helpful in stopping the bleeding caused from a Depo-Provera shot, according to About Health. When continuous bleeding occurs following a Depo-Provera shot, speak with a doctor to determine if these options are right for the situation.
Estrogen replacement therapy comes in many forms such as conjugated estrogens, micronized estradiol, an estradiol patch and an estradiol vaginal ring, according to About Health. These treatments must be taken for seven to 14 days to have effect, and they work by encouraging blood clotting and promoting the growth of the uterine lining. Women who have certain risk factors for breast, ovarian or uterine cancers, or women who are estrogen intolerant should not use estrogen replacement therapies. Tranexamic acid, a synthetic derivative of the amino acid lysine, also works to encourage the clotting of blood, and is an FDA-approved treatment for heavy menstrual bleeding.
While some women may experience continuous bleeding after a Depo-Provera shot, others experience none or even the cessation of regular menstrual bleeding, according to About Health. In about 50 percent of women, excessive or continual bleeding stops after six months of receiving Depo-Provera injections. There is no way to determine before receiving an injection if a woman is susceptible to bleeding from this birth control method.