Stage IV Hodgkin lymphoma is when cancer is widespread and affects lymph nodes above and below the diaphragm, while stage IV non-Hodgkin lymphoma affects organs and more than one lymph node area in the body, according to Healthline. Stage IV lymphoma can be curable, depending on the type of the disease.
In Stage IV Hodgkin lymphoma, the cancer can be found in the lung, liver, bone marrow or cerebrospinal fluid, according to the National Cancer Institute. Stage IV Hodgkin and non-Hodgkin lymphoma have similar symptoms, including night sweats, extreme fatigue, weight loss, bone pain, loss of appetite and itching.
Stage IV Hodgkin lymphoma treatments include chemotherapy; drug combinations, such as 12 weeks of the Stanford V protocol followed by radiation; and stem cell transplant if the lymphoma does not respond to chemotherapy and medication. Treatment is considered favorable for female patients under the age of 45 with lower white blood cell count, notes the National Cancer Institute. Treatment for Stage IV non-Hodgkin lymphoma involves chemotherapy combined with chemotherapy drugs, such as prednisone and rituximab, generally lasting for six months. The five-year survival rate for Stage IV Hodgkin lymphoma is 65 percent, according to Healthline. The survival rate for Stage IV non-Hodgkin lymphoma depends on the type of lymphoma and the patient's age and ability to handle daily activities.