Spotting two weeks after a period can indicate a hormonal imbalance, problems with contraceptive devices or pills, or an infection, according to Healthline. It can also be a natural result of ovulation (the release of an egg cell), notes BabyMed.
Many women see a small amount of spotting or "breakthrough bleeding" when they ovulate, which usually occurs approximately two weeks into a 28-day cycle, states BabyMed. Women with longer cycles generally ovulate later after their last period than women with normal cycles and therefore may see spotting later.
Sometimes breakthrough bleeding is not benign and is a symptom of a serious medical problem, such as pregnancy complications, infection, uterine fibroids or polyps, and cancer of the cervix, uterus, vagina or ovaries, notes Healthline. Regular or heavy spotting should always be investigated by a doctor.