Despite misconceptions, the U.S. Food and Drug Administration has reviewed numerous studies and found no link between Splenda and cancer as of 2014, according to About Health. FDA reviews covered 110 studies and include assessments of carcinogenic, reproductive and neurological effects.
Artificial sweeteners, such as Splenda, have been the target of scrutiny related to cancer since one lab study of rats in the 1970s showed a possible cancer link to saccharin. Even though no evidence of a person getting cancer from artificial sweeteners exists as of 2014, About Health reports that Splenda and other sweeteners still deal with public concerns. The National Cancer Institute noted that the bladder cancer affecting the rats in the study relates to a mechanism that doesn't impact humans.