The majority of reviews on Amazon.com are positive, citing the product to be consistently effective, but there are some mixed reviews of neutral or negative. Positive reviews mostly reference a history of the product consistently working. Many of the negative reviews focus on items other than effectiveness, such as price.
Soothanol X2 is reviewed with a generally positive rating at Consumer Health Digest, with positives specified as the significant number of positive user reviews. However, a negative review from a user points out that the topical cream's use of menthol creates a tingling sensation that some users find to be painful instead of soothing. Additionally, this product is more expensive than its competitors, and the main focus of negative reviews at Amazon.com cite the comparatively higher price of Soothanol X2 as a drawback.