How soon does Lupron start to shrink fibroids and endometriosis?


Quick Answer

Lupron begins to shrink fibroids in about two weeks, and the full effect is seen after three months, according to Dr. William Parker on Fibroids, A Gynecologists Second Opinion. The medicine begins to decrease the pain of endometriosis in two to four weeks, according to Endofacts.com.

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Full Answer

According to Dr. Parker, Lupron prevents the ovaries from making estrogen and progesterone. When the body cannot make these hormones, fibroids shrink by about 35 percent within three months. Heavy bleeding subsides within six months. When patients stop taking the medicine, fibroids return to their original size, and heavy bleeding usually returns within three to six months.

Endofacts.com warns that women taking Lupron for endometriosis may experience increased pain during the first two weeks of treatment. After that time, pain decreases substantially in most women. A full six month course of treatment is recommended for optimal pain relief. Lupron causes the symptoms of menopause, which include hot flashes, mood swings and an increased risk of osteoporosis, which may not be reversible. For this reason, the U.S. Food and Drug Administration limits treatment with Lupron to six months or less.

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