Hydrocortisone is a common topical corticosteroid to apply to skin irritations that does not require a physician's prescription. A prescription is not necessary as hydrocortisone is a low-strength preparation, according to MedlinePlus.
Hydrocortisone provides temporary relief from an itching or irritated scalp, itches in the rectal and anal area, as well as all types of minor rashes, itches or irritations on the skin. There is also hydrocortisone for mouth sores and discomfort, MedlinePlus reveals.
The drug comes in multiple forms, including lotion, cream, spray, foam and ointment. Hydrocortisone gel, medicated cloth towels and liquid are available. Applying it at least once and not more than four times a day enhances its effectiveness in providing temporary relief from pain, states MedlinePlus.