LDL particle number is a clinically relevant, sensitive indicator of cardiovascular disease risk, notes National Center for Biotechnology Information. LDL particle number is a more sensitive indicator than measurements of the concentration of LDL cholesterol and non-HDL cholesterol.
Previous methods of assessing heart health included assessment of the LDL concentration rather than particle number, states LifeExtension. A Quebec cardiovascular study concludes that a heart attack can still occur when a patient has a low LDL concentration but a high LDL particle number, indicating the necessity of assessing the LDL particle number. The LDL particle number varies from the LDL concentration because the amount of cholesterol contained per particle changes.