Side effects of Zegerid may include abdominal pain or headache, according to WebMD. Children can be especially sensitive to its side effects. Some unlikely but serious side effects that can occur are sudden weight gain, swelling of the hands or feet, irregular heartbeat, seizures and persistent muscle spasms.
Though rare, it is possible for Zegerid’s sodium bicarbonate content to cause milk-alkali syndrome when combined with large amounts of calcium in medications, diet or supplements, explains WebMD. This serious condition has side effects of weakness, muscle aches or spasms, vomiting, mood changes and dizziness.
Zegerid may rarely cause Clostridium difficile-associated diarrhea, a severe intestinal infection. Its symptoms include abdominal or stomach pain or cramping, persistent diarrhea, fever, and blood or mucus in the stool. Proton pump inhibitors, such as Zegerid, can also increase the risk for bone fractures, primarily with longer use or higher doses, notes WebMD.
Zegerid and similar proton pump inhibitors can possibly cause vitamin B-12 deficiency, especially if taken daily for three years or more, according to WebMD. Symptoms of vitamin B-12 deficiency include numbness or tingling in the hands or feet, unusual weakness and sore tongue. Serious allergic reactions to Zegerid are rare and necessitate immediate medical care. A patient should tell the doctor of any allergies to Zegerid and similar drugs or sodium bicarbonate.