Drowsiness, sleeping difficulties and stomach irritation or cramps are common, but not severe, side effects of Midol, according to WebMD. Liver failure and blood disorders are possible severe side effects, but those are rare. Most people experience no or only mild side effects. Drugs.com still recommends that users avoid driving and other potentially unsafe tasks until they have learned how they react to the drug.
Midol is a brand name for an over-the-counter combination of acetaminophen, antihistamine and caffeine, primarily used to alleviate menstrual cramps and pains. It is. It also has a mild diuretic effect to relive bloating, according to Bayer, the manufacturer.
Pregnant or lactating women should not use Midol without consulting a physician, nor should children. It should never be taken together with the narcolepsy medicine sodium oxybate, as the combination can cause severe drowsiness and sleepiness. Other medicines that can interact negatively with Midol are anticoagulant drugs and Isoniazid, according to Drugs.com.
Drinking alcohol, or taking other drugs that cause drowsiness, together with Midol can exacerbate the effects. The combination with alcohol may also cause liver damage. Drugs.com recommends that patients abstain from alcohol, or limit their consumption to a maximum of three drinks per day.