According to Drugs.com, common side effects of KY Jelly may include burning, itching, stinging, dryness and skin rash when applied. Seek immediate medical attention if shortness of breath, hives or intense swelling of face, tongue or throat occur.
For most women, KY Jelly does not cause serious vaginal irritation. MedicineNet reports that other over-the-counter products, including vaginal douches, perfumed products such as bath soaps, and yeast infection medication, may be the real underlying causes for increased irritation. Hormonal changes, such as menopause, may also lead to vaginal dryness and itching. Seek medical advice first to rule out any potential medical issues. Reduce the use of feminine hygiene products to prevent future irritation.