Many individuals receiving shingles vaccines experience no side effects, according to the Centers for Disease Control and Prevention. When more than 19,000 clinical study participants received zoster vaccines, 36 percent reported redness at the injection site, 35 percent reported tenderness, 26 percent reported swelling and 7 percent reported itching.
Less than 2 percent of the study participants experienced serious adverse events, and there were no vaccine-related deaths, notes the CDC. The study results revealed that the shingles vaccine reduced the number of herpes zoster cases by 51 percent. All of the study participants were age 60 or older, which is the recommended age for taking the vaccine, which had a 64 percent effectiveness in participants age 60 to 69 years and was 38 percent effective for those 70 years and older.