What Are Some of the Side Effects of SAMe?


Quick Answer

Side effects of SAMe include vomiting, gas, constipation, diarrhea and dry mouth, explains WebMD. Other side effects include insomnia, headache, dizziness, sweating and nervousness. These side effects may become worse when taking higher doses of SAMe.

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People take SAMe for a variety of reasons including anxiety, depression, fibromyalgia, heart disease and osteoarthritis, claims WebMD. Other reasons to use SAMe are to treat dementia, tendinitis, Alzheimer's disease and liver disease. People may also take SAMe for Parkinson's disease, to treat attention deficit-hyperactivity disorder, seizures, multiple sclerosis and migraines.

Studies show that SAMe seems to reduce depression symptoms, and may even be as effective as prescription medications when treating depression, according to WebMD. Studies also show that SAMe is an alternative for those who do not respond to prescription antidepressants. However, it is important that people do not take both prescription antidepressants and SAMe at the same time, as dangerous drug interactions may occur.

For osteoarthritis, SAMe also works as well as aspirin in studies, states WebMD, but it can take almost twice as long before it starts working. Most people who choose to take SAMe for arthritis must take the supplement for about a month before effects occur. There is also research that shows similar effects for those who take SAMe orally for fibromyalgia, but when taking the SAMe intravenously, the same results do not occur.

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