What Are the Side Effects of Progesterone Suppositories?

Some side effects of progesterone suppositories (or progesterone vaginal) include allergic reactions, as evidenced by hives; difficulty breathing and swelling in the face, throat or mouth; headache; numbness, especially on one side of the body; impaired vision, speech or balance; pain or a heavy feeling on the chest; pain that spreads through the arm or shoulder; painful swelling in either one or both of the legs, feet, ankles or hands; nausea; stomach discomfort; fever or chills; jaundice; discolored urine or stools; loss of appetite; breast lumps; flu symptoms and signs of depression, according to Drugs.com. If the patient is experiencing these symptoms, she should call her doctor for medical advice, but if she is experiencing an allergic reaction, she should seek emergency medical treatment immediately.

Less serious side effects can include mild nausea, bloating or other stomach discomfort; diarrhea or constipation; drowsiness; dizziness; pain in the vaginal or rectal area; pain during intercourse; breast discomfort, including swelling or tenderness; joint and muscle pain; increase in the frequency of nighttime urination or vaginal discharge, itching or burning, according to Drugs.com.

Since progesterone vaginal can cause impaired vision, thinking or reactions, it is recommended that those taking the medication do not engage in activities where impaired cognitive abilities can lead to dangerous situations.