According to BeLashed.org, the prostaglandin analogues used in Lash MD to stimulate eyelash growth can cause eye irritation, itching, eye pain and darker pigmentation around the eye. Some of these changes are permanent, and the long-term effects are unknown.
Prostaglandin analogues, the active ingredients in Lash MD and other products used to stimulate eyelash growth, can cause eye irritation, itching, eye pain and darker pigmentation around the eye, according to the Swedish Medical Products Agency. They can also change the fatty substance around the eye, causing it to sink in, and can permanently darken light-colored eyes. A 2001 study cited on AlterNet.org says that the long-term results of these side effects, especially the pigmentation changes, are unknown and potentially very serious.
In addition to eye irritation, AlterNet.org lists the potential side effects to prostaglandin analogues in eyelash serums as an inflammation called uveitis, macular edema, cataract, reduced intraocular pressure and vision problems. It also states that prostaglandin analogues can reactivate herpes simplex keratitis and warns that contact lenses and the applicator tool can become contaminated.
Most reviewers of the product, including those on XOVain.com, include reports of redness and swelling around the eyes. Others report initial eyelash growth and then significant falling out, says AlterNet.org.
As of 2015, Lash MD does not have FDA approval. It is banned in the state of Tennessee because of this, according to XOVain.com. In 2012, the Swedish Medical Products Agency banned the sale of eyelash serums that use prostaglandin analogues, including Lash MD.