Side effects of oxymetazoline nasal spray include sneezing and stinging, burning or dryness inside the nose. These side effects don't usually require medical attention, according to Drugs.com. Side effects that demand immediate attention from a doctor include blurred vision, irregular heartbeat, headache and high blood pressure.
People taking oxymetazoline nasal spray should check with a doctor immediately if they experience a headache, dizziness or drowsiness or if they feel light-headed, according to Drugs.com. High blood pressure that occurs while taking the medication also requires immediate medical attention.
In some people, taking oxymetazoline nasal spray can result in an increase in nasal congestion, particularly if they use the medicine for more than three days. This is called rebound congestion, according to Drugs.com.
Oxymetazoline nasal spray can also cause nervousness, trembling or trouble sleeping, as reported by Drugs.com. People who experience these side effects should seek advice from a doctor.
Many people experience burning or stinging in the nose when they apply oxymetazoline nasal spray. This side effect sometimes disappears as the body gets used to the medicine, according to Drugs.com. If this side effect continues or causes concern, people can see advice from a health care professional, who may be able to help reduce it.