What Are Some Side Effects of Juice Plus?

Side effects of Juice Plus include gastrointestinal problems, rash and decreased liver function, according to the Memorial Sloan Kettering Cancer Center. Juice Plus may also interfere with cancer treatment.

Juice Plus is a nutritional supplement derived from fruits and vegetables with additional vitamins. It is typically taken for cancer prevention, cardiovascular disease and weight loss, explains the Memorial Sloan Kettering Cancer Center. However, taking Juice Plus may also lead to side effects such as gastrointestinal distress and a hive-like rash, states the University of Michigan Health System. In a clinical study, two men experienced gastrointestinal distress that was possibly due to the phytonutrient preparation of Juice Plus, notes Houston et al. in Evidence-Based Complementary and Alternative Medicine.

Though it is marketed as being suitable for cancer prevention, cancer patients should exercise caution in taking Juice Plus as its antioxidant properties are not compatible with certain chemotherapy agents and radiation therapy, says the Memorial Sloan Kettering Cancer Center. Juice Plus may also adversely affect the liver, and its use has been linked to hepatotoxicity. In a clinical study, a 51-year-old woman with endometrial cancer encountered liver issues while taking Juice Plus, according to Naing et al. in the American Journal of Medicine. After discontinuing use of the product, the woman's liver function tests normalized over four weeks.