According to data collated by MedsFacts, a medical informatics company located in Pennsylvania, hypertension, insomnia, hypersensitivity, constipation, vomiting and hypotension are some of the reported side effects of ingesting Isotonix OPC-3. However, data from the MedFacts website shows that the number of reported side effects is minimal.
Isotonix OPC-3 is designed to restore energy, electrolytes and water lost during physical exercise. According to the product information tab on the Shop.Com Isotonix OPC-3 page, the drink is formulated from red wine, grape seed and bilberry. Other ingredients include pine bark extract Pycnogenol and citrus extracts, both potent bioflavonoids.
According to a 2004 report dubbed "Flavonoids in Food and Their Health Effects" published on PubMed, flavonoids help prevent coronary heart disease and cancer and may be of benefit to people with HIV. However, an August 2000 report authored by C.F. Skibola and M.T Smith and published on PubMed warns against excessive consumption of flavonoids. According to the authors, excessively high flavonoid doses can interfere with the work of certain enzymes, cause mutation of genetic material and damage cells or tissues by causing the release of free radicals. Skibola and Smith also warn that flavonoids can easily cross into the placenta, affecting unborn fetuses in ways that, due to the paucity of research, are yet unknown.