What Are the Side Effects of Excedrin?


Quick Answer

The most common side effects of Excedrin are nausea, upset stomach and heartburn. Severe side effects happen rarely and include hearing loss, confusion, excessive tiredness and fainting, according to Drugs.com.

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Other possible side effects include ringing in the ears, dark urine, pale stools, and yellowing of the skin or eyes. Some people may experience pain in the upper-right zone of the stomach or a persistent loss of appetite, states Drugs.com.

Children with chicken pox, the flu or a fever should not take Excedrin, as it may cause a fatal condition called Reye's syndrome. Excedrin contains acetaminophen, and too much acetaminophen can cause liver damage or death. For this reason, Excedrin should be taken only as directed. Excedrin can cause stomach or intestinal bleeding. Possible signs of internal bleeding are tarry or bloody stools, and coughing up unusual blood or vomit, notes Drugs.com.

Although it rarely happens, acetaminophen may cause redness or a rash on the skin that blisters and peels. If this happens, a physician should be contacted immediately. People with existing medical conditions should consult a health care professional before taking Excedrin. People with extremely severe headaches should speak to a doctor before taking Excedrin. Alcohol should not be consumed with Excedrin, as it may increase the risk of internal bleeding or liver damage. Woman should not take Excedrin while nursing, states WebMD.

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