Side effects of creatine serum supplements include stomach cramping, diarrhea, nausea and dizziness, according to examine.com nutrition experts. These symptoms increase in occurrence when the patient does not drink enough water or takes too much creatine at one time; the maximum recommended allowance is 10 grams daily, according to the U.S. National Library of Medicine.
Higher risks of renal dysfunction can occur in patients with a history of renal disease or those taking nephrotoxic medications, PubMed reports. Long-term side effects include increased toxins in the body that most likely negatively impacting kidney function. Less common psychological issues may also result, such as anxiety and depression.
Creatine is typically taken daily; of the different forms of creatine available on the market, creatine monohydrate is the cheapest and most effective form, according to examine.com nutrition experts. Micronized creatine is easier to dissolve in water, making it the preferred supplement of many users.
Existing medical conditions and prescription drug use should be considered prior to taking creatine, as many drug interactions are widely unknown. To alleviate negative side effects, proper hydration, modest dosages and physician consultation is highly recommended; the use of creatine by pregnant women and individuals with kidney disease is discouraged.