Some possible short-term side effects of cortisone injections are bruising, depigmentation, muscle pain and inflammation at the injection site, as explained by WebMD. Some other possible side effects can be weakening of tendons, damage to nerves near injection site and bones can become thin, leading to osteoporosis, as noted by Mayo Clinic.
Although a rare side effect, patients who require more frequent or higher doses of cortisone may suffer severe damage to bones that are near joints requiring the medication. This can lead to a condition called osteonecrosis or avascular necrosis, which is bone death.
The administration of cortisone injections to patients who have diabetes, may cause an increase in blood sugar. Long-term side effects of cortisone injections can be dependent on factors, such as dosage amount and how frequent shot are needed by a patient, as stated by WebMD.
Cortisone injections can be administered in either joint or soft tissue sites. Cortisone injections are useful for conditions, such as osteoarthritis, tendinitis, gout and Morton's neuroma, according to Mayo Clinic.