Some side effects of using forskolin, the chemical derived from the Coleus forskohlii plant, include low blood pressure and increased risk of bleeding for users with bleeding disorders, according to WebMD. The herbal supplement may also cause excessive bleeding during and after surgical procedures.
Forskolin is not recommended for use during pregnancy, warns WebMD. The herbal supplement can stop growth of the fetus if taken in large doses. It is not yet determined whether the herbal supplement is safe to take when breastfeeding. Flushing is another possible side effect when taking forskolin intravenously. If the herbal supplement is inhaled, it can cause coughing, tremors, throat irritation and restlessness; when taken as an eye drop, it can cause stinging.
Since forskolin lowers blood pressure, it is not recommended for patients with a history of heart disease or for patients who already take medication for high blood pressure, indicates WebMD. The herbal supplement also interacts with nitrates, which are drugs that increase blood flow to the heart. Forskolin has moderate interactions with anticoagulant and antiplatelet drugs. Since the supplement can slow blood clotting, patients should be cautious when taking the supplement in conjunction with aspirin, ibuprofen, naproxen and other drugs that also slow blood clotting.