The side effects of Depo-Provera include irregular menstruation, headaches and nervousness, according to WebMD. Other possible side effects are dizziness and depression. Some users also experience acne or changes in appetite.
Most of the side effects of Depo-Provera are uncommon, as explained by WebMD. About half of all women who take Depo-Provera cease to have their periods after the first year. For women who take Depo-Provera for more than two years, there is a higher risk of osteoporosis and other issues with bone density. Doctors recommend that women on Depo-Provera take calcium and vitamin D supplements in order to help prevent bone loss and osteoporosis.