A comparison study found no statistical difference in the efficacy of treatment between the Nasonex and Flonase, according to the National Center for Biotechnology Information. Both are corticosteroid nasal sprays that work similarly for the treatment of rhinitis.
Flonase treats allergic and non-allergic rhinitis. Fluticasone propionate is the generic form of the medication, which patients typically spray in each nostril one to two times per day, explains MedlinePlus. Nasonex, whose active ingredient is mometasone, also treats both allergic and nonallergic rhinitis, and patients spray it one to two times per day in each nostril, according to Medscape. Patients can also use both nasal sprays for the treatment of nasal polyps, notes Mayo Clinic.
Corticosteroid nasal sprays relieve symptoms of rhinitis by decreasing swelling of the nasal mucosa and by reducing mucus production, states MedlinePlus. Studies have shown that corticosteroids inhibit inflammatory cytokines to reduce swelling while also inhibiting the function of monocytes and macrophages. This process is not entirely understood, according to the National Center for Biotechnology Information .
The side effects of both medications include stinging or burning in the nose after use, sore throat, nasal ulcers, infection of the nasal passages, hypercorticism, and candidiasis of the mouth and nose, notes MedlinePlus. In rare cases nasal perforation may occur.