According to WebMD, sciatica can be treated by over-the-counter medications, prescription muscle relaxants, antidepressants and prescription pain medications as well as with physical therapy. In severe cases, sciatica may require surgery.
WebMD explains that the sciatic nerve runs from the lower spine down the back of both legs. This nerve can easily become irritated and cause pain that shoots down the back of the thigh. The pain can range from mild and burning to sharp and tingling. The irritation and inflammation of the sciatic nerve can be treated with a variety of medications and therapies. Many patients may use more than one treatment to relieve their symptoms, such as physical therapy and over-the-counter drugs.