There isn’t one over-the-counter anti-inflammatory drug that is safer than the rest. All anti-inflammatory medicines have side effects, and the benefits and risks vary from person to person, explains WebMD.
The potential side effects of anti-inflammatory drugs are different for each person. Some prescription anti-inflammatory drugs have serious side effects such as heart risks. Even over-the-counter anti-inflammatory drugs, intended for long-term use, can have similar side effects. Some possible side effects include gastrointestinal damage, skin reactions, heart attacks, strokes, kidney damage and high blood pressure, states WebMD. Patients should work with their doctors to determine which anti-inflammatory medicine poses the least risk.