It is safe to take ibuprofen and Paracetamol (acetaminophen) together, says NHS Choices. Ibuprofen and acetaminophen are two different types of painkillers, and no interactions appear to exist between them.
Ibuprofen and acetaminophen each have their own pros and cons. Some people may find that one works better than the other, or that one works better for certain types of pain, such as headache, while the other works better for fever. Individuals with questions about which drug to take or whether to take two together should always consult a doctor or pharmacist familiar with their condition. For those cleared to take either, alternating the two drugs can minimize any negative side effects associated with either, states NHS Choices.