Running 10 miles per hour, or one mile every six minutes, uses 733 calories of energy in 30 minutes for someone who weighs 185 pounds, according to Harvard Medical School. This is the highest calorie-burning activity listed on Harvard's chart that compares calorie usage of more than 100 physical activities.
Running slower uses fewer calories. A 185-pound runner moving one mile every seven minutes burns 644 calories in 30 minutes, and one mile every eight minutes delineates 555 burned calories. Running a mile in nine minutes equates to 488 used calories per half hour, whereas 10 minutes for a mile is 444 calories, notes Harvard. Someone who weighs less burns fewer calories for the same activity. The only activity that burns as many calories in 30 minutes of running 10 mph is bicycling greater than 20 mph.
To lose weight, a patient must use more calories during physical activity than the amount of calories consumed from food, notes WebMD. Someone who burns 500 more calories per day than that person consumes daily should lose up to two pounds per week. Someone who wants to lose weight faster should exercise more and eat less. For example, a 250-pound person who consumes between 1,050 and 1,200 calories per day can lose three to five pounds in the first week of a diet by exercising one hour per day.