Pain or cramping during the procedure is the most common risk associated with an endometrial biopsy. Less common risks include feeling lightheaded, infection, prolonged bleeding and perforation of the uterus, notes MedicineNet.
Taking nonsteroidal anti-inflammatory drugs 30 to 60 minutes before the procedure helps reduce pain and cramping, explains MedicineNet. The physician also minimizes discomfort caused during the procedure by spraying the cervix with numbing medicine, according to the American Academy of Family Physicians.
The thin plastic catheter used in the procedure sometimes causes a hole in the wall of the uterus. This is known as perforation of the uterus, and it is a rare risk associated with endometrial biopsies, says American Academy of Family Physicians.